miR-31 controls osteoclast formation and bone resorption by targeting RhoA
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چکیده
منابع مشابه
miR-31 controls osteoclast formation and bone resorption by targeting RhoA
INTRODUCTION Increased activity of osteoclasts is responsible for bone loss and joint destruction in rheumatoid arthritis. For osteoclast development and bone resorption activity, cytoskeletal organization must be properly regulated. MicroRNAs (miRNAs) are endogenous small noncoding RNAs that suppress expression of their target genes. This study was conducted to identify crucial miRNAs to contr...
متن کاملChapter 3. Osteoclast Biology and Bone Resorption
66. Fuentealba LC, Eivers E, Ikeda A. Hurtado C, Kuroda H, Pera EM, De Robertis E M 2007 Integrating patterning signals: Wnti GSK3 regulates the duration of the BMP/Smadl signal. Cell 13 1 : 980-993. 67. Sapkota G, Alarcon C, Spagnoli FM, Brivanlou AH, Massague J 2007 Balancing BMP signaling through integrated inputs into the Smadl linker. Mol Cell 25:441454. 68. Nakayama K, Tamura Y, Suzawa M,...
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Regulation of RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclast differentiation is of current interest in the development of antiresorptive agents. Osteoclasts are multinucleated cells that play a crucial role in bone resorption. In this study, we investigated the effects of N-methylpyrrolidone (NMP) on the regulation of RANKL-induced osteoclastogenesis. NMP inhibited RA...
متن کاملHuman osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis.
OBJECTIVE To determine whether synovial macrophages and monocytes isolated from patients with rheumatoid arthritis patients are capable of differentiating into osteoclastic bone resorbing cells; and the cellular and humoral conditions required for this to occur. METHODS Macrophages isolated from the synovium and monocytes from the peripheral blood of rheumatoid arthritis patients were culture...
متن کاملRhoA controls furrow formation
vidence that the cytokinetic apparatus is dependent on spindle microtubules comes primarily from classical experiments in which the spindle was manually moved or disrupted. On page 91, Bement et al. reveal the physiology that underlies these findings. Active RhoA localizes to a narrow zone at the site of future furrow formation in a microtubule-dependent manner, and the RhoA zone moves in respo...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2013
ISSN: 1478-6354
DOI: 10.1186/ar4282